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| Drug : Warfarin |
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Brands
Coumadin®, Jantoven®, Lawarin®, Marevan®, WarfarinPlus®, WarfarinQ®
Common Usages
Commonly used oral anticoagulant for the prevention and treatment of thrombosis and embolism in patents with deep vein thrombosis, atrial fibrillation, or prosthetic heart valve.
Adverse Drug Reactions
Hemorrhage (bleeding) due to overdoes. Hemoptysis (cough up blood), excessive bruising, bleeding from nose or gums, or blood in urine or stool. Stroke may occur when under-dosed.
Regulatory Agencies’ Announcements
2007/08/16 - U.S. Food and Drug Administration (FDA)
"FDA approved updated labeling to include pharmacogenomics information to the CLINICAL PHARMACOLOGY, PRECAUTIONS, and DOSAGE AND ADMINISTRATION sections of the prescribing information for the widely used blood-thinning drug, Coumadin. This new information explains that people's genetic makeup may influence how they respond to the drug. Specifically, people with variations in two genes may need lower warfarin doses than people without these genetic variations. The two genes are called CYP2C9 and VKORC1. The CYP2C9 gene is involved in the breakdown (metabolism) of warfarin and the VKORC1 gene helps regulate the ability of warfarin to prevent blood from clotting..."< more >
Scientific Studies & Publications
Additional information on Medical Applications & Adverse Drug Reactions
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