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| Drug : Carbamazepine |
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Brands
Tegretol®, Tegretol® XR, Tegretol® CR, Carbatrol®, Epitol®, Carbama®, Carbamaze®, Equetro®
Common Usages
Carbamazepine is an anticonvulsant, antiepileptic drug and mood stabilizing drug commonly used to treat epilepsy, bipolar disorder, and trigeminal neuralgia. Its off-label use for a variety of indications, including attention-deficit hyperactivity disorder (ADHD), schizophrenia, phantom limb syndrome, paroxysmal extreme pain disorder and post-traumatic stress disorder.
Adverse Drug Reactions
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most serious and life-threatening ADR with a 10-50% mortality rate.
Regulatory Agencies’ Announcements
2007/12/12- U.S. Food and Drug Administration (FDA)
"Dangerous or even fatal skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis), that can be caused by carbamazepine therapy, are significantly more common in patients with a particular human leukocyte antigen (HLA) allele, HLA-B*1502." < more >
2007/09/26- Department of Health, Taiwan (DOH)
"A milestone towards personalized medicine in Taiwan preventing Adverse Drug Reactions (ADR) with a gene test from post-ADR compensation to preemptive (pre-prescription prevention)." < more >
Scientific Studies & Publications
Additional information on Medical Applications & Adverse Drug Reactions
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