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| Drug : Allopurinol |
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Brands
Zyloprim®, Allohexal®, Allosig®, Progout®, Zyloric®
Common Usages
Commonly used to treat hyperuricemia and its complications, including gout. It is used to reduce uric acid level in patients receiving cancer chemotherapy, and also used to treat certain type of kidney stones.
Adverse Drug Reactions
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are two of the most serious and life-threatening ADR with a 10 - 50% mortality rate.
Regulatory Agencies’ Announcements
2009/09/01- Department of Health, Taiwan (DOH)
"...Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis (SJS/TEN) has significant statistical correlation with Human Leukocyte Antigen (HLA-B*5801) gene...", "Before using allopurinol treatment, it is necessary to consider testing for possession of HLA-B*5801 gene." < more >
Scientific Studies & Publications
Additional information on Medical Applications & Adverse Drug Reactions
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