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| Drug : Abacavir |
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Brands
Ziagen®, Epzicom® (containing Abacavir, Lamivudine)
Common Usages
Abacavir is an antiviral medication used in combination with other antiretroviral drugs [abacavir and lamivudine (Epzicom); abacavir, lamivudine, and zidovudine (Trizivir)] for the treatment of HIV-1 infection.
Adverse Drug Reactions
Hypersensitivity (also called hypersensitivity reaction) refers to undesirable reactions produced by the normal immune system. These reactions may be damaging, uncomfortable, or occasionally fatal.
Regulatory Agencies’ Announcements
2008/07/24- Serious and sometimes fatal hypersensitivity reactions (HSR)
"...caused by abacavir therapy are significantly more common in patients with a particular human leukocyte antigen (HLA) allele, HLA-B*5701. Abacavir HSR is a multi-organ syndrome characterized by 2 or more clinical signs or symptoms that can include fever, rash, gastrointestinal symptoms, respiratory symptoms and constitutional symptoms." < more >
Scientific Studies & Publications
Additional information on Medical Applications & Adverse Drug Reactions
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