DNA Genetic Tests
Relating to Disease:
RT-PCR & SYBR Green based detection method: each sample requires only 2 PCR rxns for detecting of HLA-B*27 and Internal Control. Analysis is based on Ct values.
- Required only hours from blood sample to results.
- Designed for easy operation & analysis.
- High sensitivity of major HLA-B*27 subtypes which include HLA-B*2701 ~ 2707.
- Mix & Match design.
The presence of HLA-B*27 allele is strongly associated with ankylosing spondylitis (AS), a chronic inflammatory disease of the axial musculoskeletal system and a few other rheumatic disorders (Reiter's syndrome, acute anterior uveitis, and inflammatory bowel disease). HLA-B*27 testing is routinely used to screen for AS since ~90% of patients with AS have the HLA-B*27 allele. The geographical distribution of the different subtypes of HLA-B*27, with HLA-B*2705 being common in Caucasians and American Indians, HLA-B*2704 and 2706 in Asians and HLA-B*2702 in Mediterranean populations.