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DNA Genetic Tests: HLA-A*3101 Detection

  • Required only hours from blood sample to results
  • Designed for easy operation & analysis

The HLA-A*3101 allele is associated with Carbamazepine (CBZ)-induced hypersensitivity reactions in patients of Northern European and Japan ancestry. HLA-A*3101 is located on chromosome 6 and belongs to the family of human leukocyte antigens. Detection of this allele can be used to identify patients who may be at greater risk of CBZ-induced hypersensitivity reactions.

 
Table : HLA-A*3101 Typing
Genomic DNA
Sample #
DNA Sequencing
Pharmigene RT-PCR
Positive (+)
Negative (-)
Positive (+)
Negative (-)
 False +
Healthy Volunteers
91
4
87
7
84
3
Total
91
4
87
7
84
3
 
  HLA-A*3101 Test  
 
 
  • PCR Master Mix inc. SYBR Green
  • HLA-A*3101 Detection Mix
  • Internal Control Detection Mix
  • Positive Control Templates
 
  Workflow  
   
   
 
     
 
 
 
 
  Genetic Tests
Abacavir
   - HLA-B*5701 RT-PCR

Allopurinol
   - HLA-B*5801 RT-PCR
   - HLA-B*5801 Gel

Carbamazepine
   - HLA-B*1502 RT-PCR
   - HLA-B*1502 Gel
   - HLA-A*3101 RT-PCR

Phenytoin
   - HLA-B*1502 RT-PCR
   - HLA-B*1502 Gel

Warfarin
   - VKORC1 Test
   - CYP2C9*2 Test
   - CYP2C9*3 Test

 
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