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DNA Genetic Tests: HLA-B*1502 Detection
- Required only hours from blood sample to results
- Designed for easy operation & analysis
- Validated accuracy with 4500+ patients samples* & DNA sequencing
- Protected by US, Europe, & world wide patents
- CE Marked IVD Kit Product Sheet <download - A4 / Letter>
Many studies have demonstrated the strong association of Human Leukocyte Antigen (HLA-B*1502) and carbamazepine, phenytoin, & oxcarbazepine induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Individuals that use DNA tests to determine their HLA genotypes prior to taking these drugs can reduce their risks of developing SJS/TEN by as high as 1300 times. |
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Table : HLA-B*1502 Typing |
Genomic DNA |
Sample # |
DNA Sequencing |
Pharmigene RT-PCR |
Ethnicity of Healthy Volunteers |
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Positive (+) |
Negative (-) |
Positive (+) |
Negative (-) |
False + |
Taiwan |
100 |
9 |
91 |
9 |
91 |
- |
Thailand |
51 |
7 |
44 |
7 |
44 |
- |
Indonesia |
51 |
17 |
34 |
21 |
30 |
4 |
Philippine |
49 |
4 |
45 |
9 |
40 |
5 |
India |
46 |
2 |
44 |
2 |
44 |
- |
Vietnam |
49 |
15 |
34 |
15 |
34 |
- |
Han Chinese |
170 |
15 |
155 |
15 |
155 |
- |
Caucasian |
100 |
- |
100 |
- |
100 |
- |
Total |
616 |
69 |
547 |
78 |
538 |
9 |
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HLA-B*1502 Test |
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HLA-B*1502 FastGel Test |
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- PCR Master Mix inc. SYBR Green
- HLA-B*1502 Detection Mix
- Internal Control Detection Mix
- Positive Control Templates
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Workflow |
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- PCR Master Mix
- HLA-B*1502 + Internal Control Mix
- Positive Control Templates
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Workflow |
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| Our HLA-B*1502 detection test is unable to distinguish the following rare allele types: HLA-B*1513, 1531, 1555, 1588, 1589, 1820, 9512, 9521, 9544, 9570 |
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