De novo Genome Assembly

  Bionano Genomics’ Next-Generation Mapping (NGM) visualizes long DNA molecules in their native state. Long range genomic structural information is preserved and directly observed instead of algorithmically inferred as in sequencing approaches. These long labeled molecules are de novo assembled into physical maps spanning the whole genome.

Figure 1. Molecules and labels detected in images by Bionano Genome Mapping Systems.

 

Figure 2. Hybrid-scaffolding NGS sequence assembly with Bionano maps

 

Table 2. Use of input assemblies in scaffolding.

 

Table 1. Assembly statistics for a number of human reference genomes