Bionano Genomics

  When constructing de novo genomes, short-read or long-read sequencing alone is not sufficient to construct a contiguous and accurate assembly. Next-Generation Sequencing (NGS) technologies are essential for nucleotide-level information but are limited beyond that resolution as the fragmented reads are too short to retain the contiguity needed to make a complete map and overcome repetitive regions within and between genes.

  To detect variation and architecture on a larger scale, use Bionano genome mapping, the technology that directly measures the genome with a resolution matching the variation in question—hundreds of kilobases, not hundreds of base pairs. Adding Bionano maps to sequencing data enables one to view a whole genome, with all its features in context and functional relationships described—across megabases.