PharmiGene

Do you know...
a simple genetic test can personalize medicine for you and reduce adverse drug reactions?

Adverse Drug Reactions (ADR) describes injurious effects associated with therapeutic drugs at normal dose. Some adverse drug reactions are not very serious, but others cause death, prolong hospitalization, and permanent disability. Millions of people are affected by ADR in world each year. Although most adverse drug events can be avoided with attentive patient care, some adverse events are difficult to detect or to prevent in a timely manner. More than 1 million Americans are hospitalized due to ADR each year.

Since the completion of the human genome sequences, personalized medicine based on individual’s genomic profiles is now possible. For example, scientists have identified that patients with a specific genetic marker can have over thousand folds increase their chance of severe adverse reason to specific drug. Using a companion genetic IVD test a safer and more effective drug for patients has become a reality. Browse through our website and see if we can help you.

News...
FDA announcements:
Carbamazepine- Dangerous Skin Reactions from Carbamazepine (March 2008)
Phenytoin- Serious Skin Reactions in Asian Patients on Epilepsy Drugs

September 3, 2009: Department of Health, Taiwan request updating of allopurinol’s product labeling to include information on association of Stevens-Johnson syndrome and Toxic Epidermal Necrolysis and HLA-B*5801 ... < more >

Science...
Ming Ta Michael Lee, et.al. VKORC1 haplotypes in five East-Asian populations and Indians. Pharmacogenomics 2009
< more >

Tassaneeyakul, Wichittra et.al. Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population. Pharmacogenetics and Genomics 2009 (Published Ahead-of-Print) < more >

Brands*	Genetic Tests	Common Usages*	ADR*
Coumadin® Jantoven® Lawarin® Marevan® WarfarinPlus® WarfarinQ®	VKORC1-1639 Detection CYP2C9-2 Detection CYP2C9-3 Detection	Commonly used oral anticoagulant for the prevention and treatment of thrombosis and embolism in patents with deep vein thrombosis, atrial fibrillation, or prosthetic heart valve.	Hemorrhage (bleeding) due to overdoes. Hemoptysis (cough up blood), excessive bruising, bleeding from nose or gums, or blood in urine or stool. Stroke may occur due to under-dose.

*This information is not intended to substitute for the expertise and judgment of your medical physicians, pharmacist, or other healthcare professionals.

Brands*	Genetic Tests	Common Usages*	ADR*
Zyloprim® Allohexal® Allosig® Progout® Zyloric®	*HLA-B 5801 Detection**	Commonly used to treat hyperuricemia and its complications, including gout. It is used to reduce uric acid levels in patients receiving cancer chemotherapy, and also used to treat certain type of kidney stones.	Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)

*This information is not intended to substitute for the expertise and judgment of your medical physicians, pharmacist, or other healthcare professionals.

Brands*	Genetic Tests	Common Usages*	ADR*
Tegretol® Tegretol® XR Tegretol® CR Carbatrol® Epitol® Carbama® Carbamaze® Equetro®	*HLA-B 1502 Detection**	Commonly used to treat epilepsy, bipolar disorder, and trigeminal neuralgia. Anticonvulsant or antiepileptic drug and mood stabilizing drug. Its off-label use for a variety of indications, including attention-deficit hyperactivity disorder (ADHD), schizophrenia, phantom limb syndrome, paroxysmal extreme pain disorder, and post-traumatic stress disorder.	Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)

*This information is not intended to substitute for the expertise and judgment of your medical physicians, pharmacist, or other healthcare professionals.

Brands*	Genetic Tests	Common Usages*	ADR*
Dilantin® Dilantin®Infatabs® Dilantin-125® Diphenylan® Dilantin®Kapseals® Phenytek®	*HLA-B 1502 Detection**	Commonly used to prevent and control seizures. Anticonvulsant or antiepileptic drug. This drug may also be used to treat certain types of irregular heartbeats and painful nerve conditions (e.g. trigeminal neuralgia).	Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)

*This information is not intended to substitute for the expertise and judgment of your medical physicians, pharmacist, or other healthcare professionals.